Short Tandem Repeats (STR)

Microsatellites or simple sequence repeats are short tandemly repeated DNA sequences that have a repetitive unit of 1-6 bp and form series with lengths of up to 100 nucleotides. These DNA sequences are referred to as short tandem repeats (STRs) (nt). Prokaryotes and eukaryotes, including humans, frequently include STRs. They make up roughly 3% of the entire human genome and are distributed very uniformly across the genome. They do not, however, show as frequently in subtelomeric regions, indicating that their distribution within chromosomes is not entirely uniform. Only roughly 8% of STRs are present in the coding areas, which make up the majority of STRs.

STRIDE DB

STRIDE DB is a specialized database designed to investigate the instability and diversity of Short Tandem Repeats (STRs) and their relevance to phenotypic traits. It provides a comprehensive collection of STR loci across the human genome, along withcons information on their repeat sequences, genomic coordinates, and population-specific allele frequencies. Additionally, STRIDE DB integrates data on the association of STRs with various phenotypic traits, including GWAS and ClinVar markers near the STR loci. This valuable resource allows researchers to explore the functional implications of STR variability and its potential role in phenotypic diversity, ultimately advancing our understanding of the complex relationship between genetic variation and traits.

Clincally associated variants near STRs

GWAS markers near to STRs

Conservation score on STR loci

Alu-elements near to STRs

Population-based STR frequencies

Haploblock near to STRs